From Florence: motorway A1, exit Val di Chiana - in the direction of Torrita di Siena - Pienza - San Quirico d'Orcia (30 Km from the tollgate)

From Rome: motorway A1, exit Chiusi Chianciano Terme - in the direction of Chianciano - Montepulciano - Pienza - San Quirico d'Orcia (36 Km from the tollgate)

From Siena: SS 2 Cassia in the direction of San Quirico d'Orcia - (40 Km from Siena)